Clinical Features of Wilson’s disease

Organ	Symptom	
Cornea	Kaiser-Fleischer ring	
Lens	“Sunflower cataract”	
Liver	Asymptomatic elevation of serum AST, ALT
Acute hepatitis with mild hemolytic anemia and depressed serum uric acid level (renal tubular losses)
Fulminant hepatic failure 
Chronic active hepatitis
Cirrhosis
Cholelitiasis
Hepatocellular carcinoma 	
Central Nervous System	Extrapiramidal or cerebellar dysfunction
Psychiatric symptoms (anxiety, depression, antisocial behavior)	
Kidney	Proximal tubular dysfunction
Distal tubular dysfunction	
Heart	Left ventricular hypertrophy
Arrhythmia
Autonomic dysfunction	
Bones and joints
	Demineralization
Osteomalacia
Degenerative arthritis	
Blood	Intravascular coagulation	
Skin	Hyperpigmentation